Endocrine Abstracts

Fat distribution influences metabolic risk. Accumulation of fat in the upper body increases metabolic risk, while lower body adipose expansion is protective. Oestrogen promotes lower body adiposity; transgender women on oestrogen therapy show increases in gluteal adipose, while transition to the menopause is associated with a shift in fat distribution towards the upper body, concurrent with changes in metabolic risk. Still, mechanisms governing the depot-specific effects of oe...